Screening the extraction process of phenolic compounds from pressed grape seed residue: Towards an integrated and sustainable management of viticultural waste

The integrated valorisation of waste from the food chain to obtain value-added compounds with biological functionality will facilitate transition era a sustainable bioeconomy. To this end, an efficient matrix solid-phase dispersion (MSPD) extraction method was developed and optimized, using experimental factorial design response surface methodology, for polyphenols recovery pressed grape seeds obtained after essential oils by cold pressing. Gallic, dihydroxybenzoic, p -coumaric trans -ferulic acid, naringin, resveratrol, quercetin kaempferol were quantified at 2.1–295 ?g g ?1 capillary liquid chromatography coupled diode array detector mass analyser (cLC-DAD-MS). Furthermore, total antioxidant activity, free radical scavenging lipid peroxidation suppression, together inhibition beta-amyloid (?? 42 ) protein aggregation, considered one main pathological effects Alzheimer's disease, evaluated. Potent (IC 50 0.238 ± 0.003 ng observed, along reduction ?? fibril width (9.4–54.8%) aggregation. results presented proved that MSPD could be as methodology produce phenolic-rich extracts may serve alternative neuroprotective ingredient or pharmaceutical formulations, leading cascade winery by-products. • tool waste. Hydroethanolic seed residue rich in catechin. Grape show promising neuroprotection inhibiting High revealed extracts. Phenolic spent wine residues can act high-end preservatives.